Efficacy and safety of ultrasound-guided high-intensity focused ultrasound for uterine adenomyosis: Preliminary experience from a case series

Objective: This prospective cohort study was to evaluate the efficacy and safety of ultrasound-guided High-Intensity Focused Ultrasound (HIFU) in treatment uterine adenomyosis. Methods: Ten premenopausal women with symptomatic adenomyosis underwent HIFU therapy. Their symptoms were compared using symptom severity scores before at 3, 6 12 months after treatment. The sizes their uteri adenomyotic lesions those pre-treatment as determined by magnetic resonance imaging. Results: menstrual pain reduced 45.5% (-83.3–100%) 3-month, 57.3% 6-month 27.9% (-100–100%) 12-month modified Uterine Fibroid Symptom Quality Life 50.0% (9.1–69.7%) 40.9% (27.3–66.7%) 39.5% (0–70.0%) uterus volumes 24.4% (1.2–42.0%) 46.3% (2.1-78.4%) treatment, respectively. Two patients (20%) had significant treatment-related complications three (30%) required subsequent surgical interventions. Conclusions: Although appears provide relief most adenomyosis, its long-term effectiveness require further evaluation a larger patients, may improve clinical experience.